Mechanism of action of the drug
The mechanism of action of Sinulox is based on the properties of its active components.
The product contains two active ingredients: the main one is amoxicillin, and the additional one is clavulanic acid. The first blocks the activity of bacterial enzymes, which leads to the destruction of their cell membranes and the death of microbes. Some bacteria are capable of producing a substance that destroys the antibiotic even before it takes effect. To prevent this from happening, the manufacturer added clavulanic acid to Sinulox. It inhibits the activity of the enzyme, protecting amoxicillin from destruction and providing the therapeutic effect of the drug.
When is Sinulox prescribed?
Indications for the use of the antibiotic Sinulox may include the following disorders in cats caused by microorganisms:
- purulent inflammatory processes on the skin (pyodermitis and others);
- diseases of the urinary and reproductive systems (endometritis, cystitis);
- pathologies of the mucous membranes and soft tissues of the oral cavity (for example, stomatitis);
- infectious processes developing after injury, surgical procedures;
- diseases of bacterial origin in newborn kittens;
- diseases of the respiratory system (pneumonia, rhinitis and others).
How to use Synulox
The use of Synulox for the treatment of cat diseases must be carried out in strict accordance with the instructions for use. When selecting a specific dose and form of the drug, the veterinarian takes into account not only the weight of the animal, but also assesses its condition, the likelihood of possible complications, the degree of development of the infectious process and other parameters, therefore spontaneous “treatment” based only on weight indicators can lead to deterioration of the cat's condition.
During treatment with tablets, as well as when giving injections, you should not skip the next dose (injection) of the drug. This can not only reduce the effort expended to zero, but also lead to bacteria becoming unresponsive to the antibiotic, weakening the animal’s body, and contributing to the worsening of inflammatory processes. If for some reason you manage to miss one dose of the medication, and there is still time to do so, then it should be done as quickly as possible. If the time has already come for administering the next dose of the drug, then it is administered without taking into account the omission, that is, the dosage does not need to be doubled.
Action of Sinulox
Due to its combined antibacterial effect, the drug is prescribed by specialists more often than other medications from the same group. The active components of Sinulox are: The main active ingredient is amoxicillin. This is a penicillin semi-synthetic antibiotic that inhibits the activity of bacterial enzymes and causes the death of pathogenic microbes.
The action of the antibiotic is facilitated by an additional activator substance - clavulanic acid. Its peculiarity is that it interferes with the ability of microorganisms to become resistant to the action of the main component, destroying the resistance of bacteria to antibiotics. A wide range of combinations of active ingredients ensures effectiveness against salmonella, streptococcus, corynebacterium and other dangerous microorganisms.
There is no toxic effect when taking Sinulox; it is easily excreted in urine and bile. The medication has hazard class 4 according to GOST 12.1.007.
The drug has two forms - suspension (40 or 100 ml) and tablets (50, 250 or 500 mg). Suspension - instructions for use. This form is used for injection, placed subcutaneously in the buttock or withers. Application can be according to the following scheme - 1 injection for 3 or 5 days, if the case is complicated - treatment is extended by a veterinarian. After injection, be sure to massage the injection site.
The calculation of a single dose of Sinulox is determined by body weight - 8.75 mg is taken per 1 kg of body weight. Accordingly, for 20 kg of weight - 1 ml of suspension. With such a set of small volumes of medicine, the problem of finding a suitable syringe arises; on the advice of a specialist, you can take an insulin one.
Sinulox injections require you to follow the following rules:
- Do not administer intravenously;
- Before administration, be sure to shake the suspension;
- The needle and syringe must be completely dry when taking the injection.
- Do not mix Sinulox with other medications in the same syringe.
Instructions for use of tablets
Sinulox tablets
According to the instructions, the tablet form of Sinulox is given to cats twice a day, regardless of food. The tablet can be given simply by hand or pre-crushed and added to food during feeding. It is important to ensure that your pet eats the entire portion of food without leaving any leftovers, otherwise the effectiveness of treatment will be low. Another option for tablet therapy is to crush the tablets, mix them with water in a teaspoon, and then pour them into the cat’s mouth, holding the jaws so that the solution does not spill out.
A single dosage of Sinulox is 12.5 mg per 1 kg of cat weight. It is allowed to increase it to a maximum of 25 mg per 1 kg in case of a serious condition of the animal or a high risk of complications and other situations. The duration of therapy is usually 1 week. For infections that are difficult to treat or a chronic course of the disease, the duration of treatment can be increased to two or more weeks.
Sinulox in suspensions
Dosage
Sinulox is prescribed per 1 kg of cat's weight - 12.5 mg of Sinulox, let's do the calculation - if one tablet contains 250 mg of the active substance, and the cat weighs 4 kg, then you will need approximately 50 mg of Sinulox. That is 1/5 tablet. In a veterinary pharmacy you can immediately buy a dosage of Sinulox 50 for cats.
The dosage when calculating a solution for parenteral administration is different - 8.74 mg of sinulox per 1 kg of weight. Insulin syringes are used for cats; they have a thin needle and a finer syringe gradation, so as not to make a mistake with the dosage.
Before putting it into a syringe, the solution must be shaken, and after administering the medicine, it is better to massage the injection site to avoid painful formations and lumps. You cannot increase or decrease the dosage of the drug on your own. Follow your veterinarian's advice regarding the duration of treatment. If the doctor thinks that you need to give the drug for 7 days and not a day more, do not kill the cat, do as prescribed by the doctor.
Instructions for use of the suspension
The Sinulox suspension is used in injection form - injections are placed under the skin in the cat's withers or gluteal muscle. The application regimen is as follows: one injection per day for 3-5 days (in some particularly difficult cases, the veterinarian may prescribe longer treatment). After giving the injection, the injection site should be gently massaged.
A single dose of the drug must be pre-calculated. The medicine is taken based on the proportion of 8.75 mg per 1 kg of cat’s body weight. This corresponds to 1 ml of suspension per 20 kg of animal weight. Often owners are faced with the problem of collecting such an amount of the drug, for example, with a small body weight. Experts advise using an insulin syringe.
When injecting Synulox, you must strictly adhere to the following rules:
- the drug cannot be injected into a vein;
- The suspension should be shaken before the injection;
- you only need to draw the suspension with a completely dry needle and a dry syringe.
Instructions for use with dosages
There are two ways to administer the antibiotic – orally and by injection. The choice depends on the condition of the animal. If the infection in a cat is severe, it is advisable to use a form that will give the fastest possible results. Only a veterinarian should prescribe the drug and calculate the dose. When calculating the dosage of Synulox in tablets, the doctor is guided by the following formula:
- for common infections: 12.5 mg per kilogram of animal body weight;
- for severe bacterial lesions: 25 mg/kg.
The medicine should be taken in the morning and evening. The tablet is given to a cat or kitten by hand or crushed and added to food. If the cat stubbornly does not want to take the drug, it can be diluted with water and injected into it using a syringe. Sometimes owners freeze the tablet in butter and feed it to the patient. It is undesirable to use this method of administration, since dairy products impair the absorption of amoxicillin and clavulanic acid. The course of treatment with tablets is about a week.
Contraindications and side effects
The drug Sinulox has few contraindications: intolerance to the components of the drug and allergies to antibiotics. It is also contraindicated to give Sinulox to cats if at this time they are being treated with bacteriostatic drugs, for example, chloramphenicol.
Side effects are also few in number, and they are observed in rare cases. If the dosage is not observed and in overly sensitive cats, the following reactions may occur:
- skin rashes;
- disorders of the digestive tract (diarrhea, difficulty defecating);
- swelling of the skin or mucous membranes;
- lacrimation.
If such symptoms are detected, the animal should be shown to a veterinarian. Perhaps he will reduce the dosage of the drug or prescribe another remedy. In some cases, the symptoms go away on their own.
Side effects and contraindications
The drug Sinulox, which belongs to the penicillin group, has prohibitions in the form of an allergic reaction to antibiotics and individual intolerance to any of the components included in the composition. The medication should not be used on cats that are undergoing therapy based on bacteriostatic agents during this period.
As for side effects, they are extremely rare and few in number. If the exact dosage is not followed by the veterinarian or pet owner, the following reactions are sometimes observed in sensitive individuals:
- rashes on the skin of varying intensity; increased lacrimation; impaired functioning of the digestive system, manifested by difficult bowel movements or diarrhea; severe swelling of the mucous membranes and skin.
If an animal being treated with an antibiotic exhibits these symptoms, it should be taken to a veterinarian immediately. The specialist must adjust the dosage of the drug or replace it with a more suitable analogue. Mild symptoms often go away on their own.
Advantages of the drug
The popularity of Synulox is based on its many benefits.
What does a Sinulox tablet look like?
- High efficiency. The use of the drug is indicated even in the case of a chronic, advanced disease or its complicated form. At the same time, the pet’s condition noticeably changes for the better after just a few days from the start of treatment.
- There are almost no contraindications for use. Sinulox can be given to newborn kittens and older animals, as well as weakened pets.
- Well tolerated. Side effects may only occur occasionally.
- Versatility. The antibiotic Sinulox has a pathogenic effect on a large number of strains of microorganisms (gram+ and gram-).
- Does not have a pronounced detrimental effect on beneficial microflora. When used correctly, the drug kills only pathogenic microbes, preserving the animal’s immune system.
- There is a choice: tablets or injections. Sometimes giving an injection to an animal is quite problematic, so you can use the tablet form.
- Easy to use. To give an injection, you do not need to mix the ingredients; the suspension is completely ready for use.
- Purchasing is hassle-free. The drug can be purchased at almost every veterinary pharmacy.
How much does Synulox cost?
The price of the antibiotic Sinulox depends on the form and volume of the product. Thus, 50 mg tablets can be purchased at a cost of 180-200 rubles per pack (10 tablets). The suspension is more expensive - for 40 ml of medicine you need to pay about 1000 rubles, and for 100 ml - more than 2000 rubles. It is worth considering that the bottle can only be stored for one month after taking the suspension from it.
Judging by the reviews, Sinulox is an absolutely safe and very effective treatment for bacterial infections in cats. The main thing is not to give it to your pet without the supervision of a specialist.
Application and dosage
The tableted drug is taken orally. Sinulox injections for cats are administered with a syringe most often into the femoral muscle, or subcutaneously, observing asepsis. Injection ampoules should be shaken before use, as the suspension is quite thick. It is also not recommended to store the injection drug directly in the syringe.
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The correct dosage of the suspension is determined according to the patient’s weight:
At the rate of 1 ml per 20 kg, which is 0.05 mg per kilogram of weight. Injections are given once a day, usually for 3-5 days, unless the doctor prescribes otherwise.
Weight of a cat and calculation of the intake of Synulox tablets when packaged in 50 mg units:
- less than 2 kg of weight - 1/2 tablet
- 3 - 5 kg - one
- 6 - 9 kg - two
- -10 – 13 kg – three
- 14 - 18 kg - four
The use of Sinulox depends on the form of the drug. Sinulox tablets are usually taken from five days to a week. The dose of the drug can be doubled for severe infections, especially pneumonia. It is not recommended to increase the single dosage of Synulox, but the daily dose can be divided into more doses, 3-4 instead of two.
Treatment of skin diseases or diseases that have become chronic requires a longer course, from two to four weeks. Chronic pneumonia or skin diseases are treated with Synulox for a week to 10 days.
