Composition and release form
The active ingredient of the drug is hyaluronic acid in the form of sodium hyaluronate at a concentration of 10 mg per 1 ml of solution. The composition includes auxiliary components in which the main compound is dissolved - sodium chloride and water for injection.
The medicine is available in the form of a colorless transparent solution for injections. It is packaged in 2 or 6 ml bottles, closed with a rubber stopper, then with an aluminum cap. The finished drug is packaged in cardboard boxes of 3 or 6 pieces. You can buy Bonharen individually at the pharmacy.
Description, composition, release form
"Bonharen" is a remedy for the treatment of arthritis, arthrosis and tenosynovitis. The basis of the drug is hyaluronic acid, which stops the processes of joint destruction and helps strengthen articular cartilage.
The composition also includes the following components:
- water for injections;
- sodium chloride.
The release form of the drug is a transparent liquid for injection, poured into bottles of 2 or 6 ml sealed with rubber caps.
There are six such bottles in a cardboard package and instructions for use are included. Drugs with an anti-inflammatory effect also include: powder for wounds with iodoform, “Gamavit”, “Stop-cystitis”, “Norocarp”, “Travmatin”, “Flexoprofen”, “Ketofen”, “Rimadyl”.
It contains information about the manufacturer, composition, indications for use, and timing of the product’s sale.
Important! The drug does not contain genetically modified substances.
Pharmacological properties
Hyaluronic acid is a compound that is present in many tissues of humans and animals. The main property of the substance is that it holds water molecules, forming a gel-like structure. Hyaluronic acid is present in synovial fluid, which coats the joints, protecting them from drying out and delivering nutrients to them.
With age, after injury and illness, the concentration of this component in the body decreases. Synovial fluid is not produced in the required amount, water molecules are not held together. The joints dry out, become weak, and the animal experiences discomfort due to the friction that arises between them.
The introduction of a drug with hyaluronic acid normalizes the situation. The substance restores the viscosity of synovial fluid and improves tissue nutrition. For joint diseases, painkillers only reduce the severity of symptoms, but it is necessary to act on the root of the problem in order to completely get rid of it.
Bonharen has the following effects:
- restores joint mobility;
- eliminates discomfort and pain;
- relieves inflammatory processes formed due to friction of dry joints;
- restores the consistency of synovial fluid;
- stimulates the restoration of damaged joint tissues;
- restores the protective function of joints.
The drug restores the animal's ability to move without discomfort. The dog becomes active again.
Bonharen
INSTRUCTIONS
on the use of Bonharen for the treatment of ophthalmic diseases
in horses, dogs and cats
(developer organization: “Contipro as” / “Kontipro JSC”,
Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic)
I. General information
Trade name of the drug: Bonharen
International nonproprietary name: sodium hyaluronate.
Dosage form: eye drops
Bonharen in 1 ml of the drug contains as an active ingredient hyaluronic acid in the form of sodium hyaluronate 10 mg and excipients: sodium chloride and water for injection up to 1 ml.
In appearance, Bonharen is a colorless transparent solution.
The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of production. After the first opening of the bottle, the drug cannot be stored.
Bonharen should not be used after the expiration date.
Available packaged in glass bottles of 2 and 6 ml. Vials of appropriate capacity are sealed with rubber stoppers, reinforced with aluminum caps, equipped with tamper evident caps and packaged in group cardboard boxes of 3 bottles. Each consumer package is supplied with instructions for use.
The medicine should be stored in the manufacturer's sealed packaging, protected from direct sunlight at a temperature of 2°C to 25°C. Do not freeze!
Bonharen should be stored out of the reach of children.
Unused medicinal product is disposed of in accordance with legal requirements.
Conditions of release: without a veterinarian's prescription.
II. Pharmacological (biological) properties
Pharmacotherapeutic group: Bonharen belongs to the group of ophthalmic moisturizers of natural origin.
Hyaluronic acid, which is part of the drug Bonharen®, is a compound of natural origin, part of connective, epithelial and nervous tissues, is one of the main components of the extracellular matrix, and is found in many biological fluids, including eye tissues. Hyaluronic acid protects the cornea from damage, prevents moisture loss, increases water retention on the corneal surface, and also increases corneal moisture due to its ability to bind water molecules. Hyaluronic acid promotes the healing of erosions on the cornea and prevents their occurrence. When applied topically, hyaluronic acid is practically not absorbed from the surface of the cornea. In terms of the degree of impact on the body, Bonharen is a low-hazard substance (hazard class 4 according to GOST 12.1.007-76), in recommended doses it does not have a local irritant or sensitizing effect, and does not have cumulative properties.
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I II. Application procedure
Bonharen is used as a moisturizer for ophthalmic diseases, including acute and chronic keratitis, conjunctivitis and keratoconjunctivitis, dry keratoconjunctivitis, ulcers and corneal injuries. In the treatment of infectious eye diseases, Bonharen is used in complex therapy with etiotropic drugs.
A contraindication for the use of the drug is individual hypersensitivity to the components of the drug.
For ophthalmological diseases, Bonharen is administered into the conjunctival sac, 1-2 drops per affected eye every 2-12 hours. The duration of treatment is 5-7 days for acute inflammation and up to 60 days for chronic pathologies (until improvement or complete cure).
No symptoms have been identified that occur during an overdose of the drug.
No specific effects of the drug were found upon first administration or upon discontinuation.
Bonharen can be used during pregnancy and lactation.
If the next treatment is missed, the use of the drug is resumed at the same dose according to the same regimen.
Adverse reactions and complications when using the drug in accordance with the instructions, as a rule, are not observed. If allergic reactions occur, stop using the drug and, if necessary, carry out desensitizing therapy.
Bonharen can be used in complex therapy of ophthalmological diseases. In case of combined use with other ophthalmic drugs, it is recommended to maintain a pause of about 30 minutes between drug administrations. The interaction of the drug with cationic drugs based on erythromycin, amoxicillin, cefkinome causes the coagulation of sodium hyaluronate. Eye ointments should be used after instilling Bonharen.
After using Bonharen, livestock products can be used for food purposes without restrictions.
IV. Personal prevention measures
When working with Bonharen, you should follow the general rules of personal hygiene and safety precautions provided for when working with medications. During work, it is prohibited to drink, eat, or smoke. After finishing work, wash your hands with soap.
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If the drug accidentally comes into contact with the skin or mucous membranes, it should be washed off with water. People with hypersensitivity to the components of the drug should avoid direct contact with Bonharen. Empty bottles of the drug must not be used for household purposes; they must be disposed of with household waste.
If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label).
Name and address of the production site of the manufacturer of the medicinal product for veterinary use.
Name, address of the organization authorized by the owner or holder of the registration certificate of the medicinal product to accept claims from the consumer
Contipro JSC, Dolni Dobrouc 401, 561 02, Czech Republic Contipro as, Dolni Dobrouc 401, 561 02 Dolni Dobrouc, Czech Republic
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Indications for use
Bonharen is intended for the treatment of joint diseases in cats, dogs and horses. Intravenous administration is prescribed in the following cases:
- arthritis (inflammation of joint tissue);
- arthrosis (dystrophic change in articular cartilage);
- osteochodrosis (ossification of cartilage with further destruction of the joint);
- tendinitis (inflammation of tendons);
- tenosynovitis (inflammation of the tendons of the genital organs in females);
- non-infectious bursitis (inflammation of the tissues of the synovial bursa);
- other joint diseases.
Instructions
The instructions for use of Bonharen say that the drug is administered intravenously. Wash your hands with disinfectant, put on disposable medical gloves, and wipe the dog's skin with alcohol. It is most convenient to inject the drug into the cephalic vein of the forearm, that is, into the upper part of the paw. A tourniquet is applied above this place.
The dosage is determined by the doctor, but usually the average values are used:
- for animals weighing less than 5 kg - 0.1 ml of solution per 1 kg of weight;
- for dogs heavier than 5 kg – 0.05 ml of solution per 1 kg of weight.
Not every owner will be able to give an intravenous injection on their own. The instructions for use indicate one more possible method of administering the medicine - subcutaneously. Then the injection is given at the withers. This injection method should be discussed with your doctor.
Depending on the disease, its severity and the dog’s well-being, the veterinarian prescribes from 3 to 7 injections. You don’t need to do them every day - you need a break of 5-7 days.
If Bonharen is used to treat eye diseases, then 1-2 drops of the medicine should be dripped into each conjunctival sac. The doctor will tell you how often to do this - between procedures there should be an interval of 2 to 12 hours. The general course of treatment is 5-7 days.
Mode of application
The injection solution is intended for subcutaneous or intravenous administration. The exact treatment regimen is determined by the veterinarian, taking into account the degree of development of the disease, the condition and age of the animal, as well as its weight. For dogs weighing less than 5 kg, Bonharen is administered at the rate of 0.1 ml per kilogram, for larger dogs - 0.05 ml/kg.
Important! The usual course of treatment is 5-7 days. Injections cannot be prescribed or canceled independently - only a doctor can assess the effectiveness of therapy.
When treating eye diseases, the solution should be dripped every 2-12 hours, 1-2 drops. If ointments and other eye medications are additionally prescribed, the interval between their use should be at least half an hour. In this case, Bonharen is first dripped, then the ointment is applied.
Contraindications and side effects
Since the composition of the drug is simple, there are almost no contraindications. Hyaluronic acid is a natural compound that is present in the body of every mammal. The only negative reaction can be caused by sodium chloride. Individual intolerance to this component is a contraindication for the use of Bonharen. For other animals, including puppies and pregnant females, the drug is harmless.
The medicine cannot be used in conjunction with cationic antimicrobial substances - erythromycin, amoxicillin, cefkin. They cause Bonharen to clot.
There are also few side effects. If a dog is allergic to the solution, then there will be characteristic symptoms - itching, redness of the skin, rash, nasal discharge, signs of inflammation in the ears, etc. Usually there are no serious manifestations, and the dog gets better without additional treatment.
Application and action of Bonharen
Bonharen is a modern effective drug for the successful treatment of joint diseases in dogs, cats, horses and other animals. It belongs to the group of chondroprotectors, restores cartilage tissue and prevents its further destruction. Injections of the drug return joints to normal functioning, eliminate pain and other manifestations of the disease.
The main active component of the drug is hyaluronic acid of natural origin, obtained from synovial fluid and connective tissues of mammals. It improves the quality of the joint fluid and its lubricity, eliminates all the consequences of the chronic inflammatory process and restores the physiological functions of the joint. Bonharen for horses, dogs and cats reduces the risk of complications of joint diseases and provides a positive effect for a long period of more than six months.
The drug is used to treat chronic tendinitis, tendovaginitis, bursitis, osteochondrosis, arthritis, arthrosis in dogs and other animals. It is administered intravenously or intramuscularly as prescribed by a doctor from 3 to 7 times with a 5-day break between injections. For the treatment of arthritis in dogs, the recommended dosage is 0.05 ml per 1 kg of weight. For cats, the dose is 0.1 ml per 1 kg of animal weight. To treat bursitis in a horse, 0.01 ml of Bonharen is used, multiplied by the weight of the animal.
Bonharen is well tolerated by animals and does not cause adverse reactions. In some cases, slight swelling and redness may appear in the injection area, which disappear within one day. The drug cannot be used together with antimicrobial agents such as erythromycin, cefquin, etc. They contain cationic substances that cause the drug to clot. Bonharen for dogs is also profitable to buy from a financial point of view. The cost of a course of treatment will be significantly cheaper compared to long-term use of other analogues of this chondroprotector.
Reviews
Ekaterina, 42 years old, Tomsk
“My Amadeus began to limp, let's go to the vet. They prescribed a course of Bonharen. I was afraid to inject myself, so every week we went to the clinic, the course lasted 1.5 months. Amadeus began to run freely. The only negative is that the drug is expensive (3 thousand rubles per bottle). We needed 3 ampoules - one was enough for 2 injections.”
Vitaly, 36 years old, Ufa
“We injected Bonharen into Rottweilers at the kennel. They gave it subcutaneously at the withers, 0.5 ml per 10 kg of weight, that is, 1 ampoule was enough for 2 injections in a dog weighing 60 kg. For the course, 3 bottles were taken for each Rottweiler. The effect is noticeable immediately – it becomes easier for the animal to walk, activity returns, and appetite improves.”
Bonharen
Name
BONHAREN
Name (Latin)
Bonharen
Composition and release form
1 ml of bonharen contains 10 mg of hyaluronic acid in the form of sodium hyaluronate as an active ingredient, and sodium chloride and water for injection as auxiliary components. The drug is a colorless transparent solution for injection. Packaged in 6 ml glass bottles and packed in 3 bottles in cardboard boxes.
Pharmacological properties
Hyaluronic acid, which is part of bonharen, is a naturally occurring compound present in connective tissue, skin, vitreous body and in the highest concentration in the synovial fluid of mammals. Hyaluronic acid normalizes the cellular composition and viscosity of the joint fluid, improves its lubricity, activates the mobility of granulocytes and macrophages, eliminates the consequences of inflammatory processes and helps restore the physiological function of the joint. Hyaluronic acid, when administered parenterally in high concentrations, accumulates in the synovial fluid, where it exerts its therapeutic effect. In terms of the degree of impact on the body of warm-blooded animals, Bonharen is a low-hazard substance; in recommended doses it does not have a locally irritating or sensitizing effect, and does not have cumulative properties.
Indications
Prescribed for horses, dogs and cats for the treatment of acute and chronic arthrosis, polyarthrosis, subacute and chronic arthritis, acute and chronic tendovaginitis, tendinitis, bursitis and osteochondrosis of non-infectious etiology, joint dysfunction accompanied by lameness, acute and chronic keratitis, conjunctivitis and keratoconjunctivitis, as well as ulcers and wounds of the cornea.
Doses and method of administration
Bonharen is administered to animals intravenously or subcutaneously at the rate of: horses - at a dose of 0.01 ml of the drug per 1 kg of animal weight, dogs weighing from 5 to 80 kg - at a dose of 0.05 ml per 1 kg of animal weight, dogs and cats weighing up to 5 kg - at a dose of 0.1 ml per 1 kg of animal weight. The course of treatment is 3–7 injections with an interval of 5–7 days. For eye diseases, the drug is instilled into animals, 1-2 drops onto the conjunctiva of the eye every 2-12 hours for 5-7 days.
Side effects
In some animals, swelling may appear at the injection site, which disappears after 24 to 48 hours.
Contraindications
Bonharen should not be used simultaneously with cationic antimicrobial substances (erythromycin, amoxicillin, cefquin), as they cause clotting of the drug.
special instructions
Products from animals to which the drug was administered are used without restrictions. When administered intravenously, strict adherence to the rules of asepsis is necessary. Bonharen can be used during pregnancy and lactation.
Storage conditions
In a dry place, protected from light and out of reach of children and animals. Separated from food and feed at temperatures from 5 to 25 °C. Shelf life: 3 years.
